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The broad market exchange-traded fund SPDR S&P 500 ETF Trust 
SPY was down 0.2% and the actively traded Invesco QQQ Trust 
QQQ retreated 0.3% in Friday’s premarket activity, amid escalating tariff concerns and FedEx’s reduced earnings forecast, signaling potential economic headwinds.
US stock futures also edged lower, with S&P 500 Index futures down 0.3%, Dow Jones Industrial Average futures slipping 0.4%, and Nasdaq futures declining 0.4% before the start of regular trading.
Federal Reserve Bank of New York President John Williams is scheduled to speak at 9:05 am ET.
The weekly Baker Hughes domestic oil-and-gas rig count posts at 1 pm ET.
In premarket action, bitcoin was down by 0.2% and the cryptocurrency fund ProShares Bitcoin Strategy ETF 
BITO was 0.2% lower.
Power Play:
Industrial
Industrial Select Sector SPDR Fund 
XLI lost 0.5% while the Vanguard Industrials Index Fund 
VIS and the iShares US Industrials ETF (IYJ) were inactive.
FedEx 
FDX stock was down more than 8% before the opening bell as the company lowered its guidance for fiscal 2025.
Winners and Losers:
Consumer
The Consumer Staples Select Sector SPDR Fund 
XLP was up 0.2%, while the Vanguard Consumer Staples Fund VDC was flat. The iShares US Consumer Staples ETF 
IYK was inactive, and the Consumer Discretionary Select Sector SPDR Fund 
XLY lost 0.2%. The VanEck Retail ETF 
RTH and the SPDR S&P Retail ETF XRT were inactive.
Nio 
NIO shares were down more than 4% pre-bell after the company reported a wider Q4 adjusted net loss and posted downbeat guidance for Q1 revenue.
Health Care
The Health Care Select Sector SPDR Fund 
XLV retreated by 0.01%. The Vanguard Health Care Index Fund VHT advanced 0.2% while the iShares US Healthcare ETF IYH gained 1.1%. The iShares Biotechnology ETF IBB was inactive.
Telix Pharmaceuticals 
TLX stock was up more than 3% premarket after the company said that the US Food and Drug Administration has approved its new drug application for Gozellix, a PSMA/PET imaging agent for prostate cancer.
Technology
Technology Select Sector SPDR Fund 
XLK retreated 0.4%, and the iShares US Technology ETF IYW was 0.8% lower, while the iShares Expanded Tech Sector ETF IGM was inactive. Among semiconductor ETFs, SPDR S&P Semiconductor ETF XSD was inactive, while the iShares Semiconductor ETF SOXX fell 0.8%.
WISeKey International 
WIHN shares were up more than 3% in recent Friday premarket activity after the company said its subsidiary SEALCOIN partnered with WeCanGroup to enable secure transactions and advanced identity verification within the WeCanGroup ecosystem.
Financial
Financial Select Sector SPDR Fund 
XLF retreated 0.04%. Direxion Daily Financial Bull 3X Shares 
FAS was down 0.5%, while its bearish counterpart Direxion Daily Financial Bear 3X Shares FAZ was 0.2% higher.
Toronto-Dominion Bank 
TD shares were down 1.5% pre-bell Friday after the company said late Thursday it plans to exercise its right to redeem all of its outstanding 3 billion Canadian dollars ($2.09 billion) 3.105% notes due April 22, 2030, on April 22, 2025.
Energy
The iShares US Energy ETF IYE was inactive, while the Energy Select Sector SPDR Fund 
XLE was down by 0.2%.
Commodities
Front-month US West Texas Intermediate crude oil retreated 0.4% to $67.35 per barrel on the New York Mercantile Exchange. Natural gas was down 1.2% to $3.93 per 1 million British Thermal Units. United States Oil Fund 
USO declined 0.5%, while the United States Natural Gas Fund UNG fell 2.4%.
Gold futures for April retreated 0.1% to $3,041.40 an ounce on the Comex, while silver futures fell 0.8% to $33.73 an ounce. SPDR Gold Shares GLD were flat, and the iShares Silver Trust SLV was 1% lower.